SproutCore
From Organic Design wiki
SproutCore applications move business logic to the browser so they can respond to your users' taps and clicks immediately, avoiding an agonizing roundtrip across often intermittent network connections.
As web application users go increasingly mobile, applications can no longer depend on reliable connections to a remote server to do the heavy lifting.
At the same time, web browsers continue to radically improve their ability to quickly process data and deliver polished user interfaces—a perfect opportunity to rethink the architecture of modern web applications.
