GemStone
From Organic Design wiki
Transparent persistent storage for Seaside
GemStone/S combines an enterprise class application server, a robust object database, and a multi-user Smalltalk virtual machine. With the addition of the open source Seaside framework, and other add-ons such as script.aculo.us, and the Pier CMS, GemStone/S provides an excellent platform for deploying dynamic web applications with transparent persistence. In addition to the GLASS Virtual Appliance, GemStone has other [editions of GemStone/S] that will run Seaside, but do not include a pre-configured operating system or Apache.