GLASS
From Organic Design wiki
GLASS –GemStone, Linux, Apache, Seaside, and Smalltalk
provides a powerful new way to rapidly create and deploy desktop-like web applications. GLASS makes GemStone's transparent persistence, enterprise scalability, and legendary reliability available to web application developers. By using GLASS, you can focus on developing your application, and not spend any time on complex Object-Relational mapping or other persistence schemes. For more details, visit the GLASS Wiki, or read Dale's or James' blog.